Interleukin 7 (IL7) is a cytokine produced by bone marrow and stromal cells of the thymus 1. Thus, il7r is an essential molecule for maintaining normal retinal development in zebrafish. Overall, our data demonstrate that a lack of il7r retards the development of the retina. Finally, the results from behavioural tests indicated that visual function was impaired in il7r −/− mutant larvae. Third, microarray analysis revealed that genes associated with the phototransduction signalling pathway were strongly down-regulated in il7r −/− mutants. Second, the gross development of il7r −/− mutants revealed remarkably smaller eyes and delayed retinal neurodifferentiation. ![]() First, an il7r −/− homozygous mutant line was generated by clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 (CRISPR/Cas9) technology. ![]() The aim of the present study was to investigate the novel function of il7r in neurogenesis. Zebrafish is an ideal model for the study of neurogenesis moreover, the il7r gene is highly conserved between zebrafish and human. ![]() Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development of the nervous system. ![]() Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Interleukin 7 receptor ( il7r), a transmembrane receptor, belongs to the type I cytokine receptor family.
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